After just one term, the Stratford sisters are making their mark on Padua High. Outspoken Kat is a known campus activist, and she's let down her guard just enough to hook up with mysterious bad boy Patrick. Meanwhile, her social-butterfly sister, Bianca, has taken on self-centered head cheerleader Chastity, and just might be dating her ex, would-be male model Joey... much to the sorrow of love-struck nerd Cameron.

Things just keep getting more interesting as these changes rock Padua's social order. Meanwhile, back at home, overprotective Dr. Stratford is NOT happy about this boy invasion, but he has ways of keeping his girls in line.