Aliens in America chronicles alien encounters that are reported by people from across America. Each one-hour episode documents three stories, including those of: two men in South Carolina, who survived an extraordinary alien abduction; twin sisters, who were used as a breeders for aliens; cold-blooded, sewer-dwelling reptoids, which are said to lurk beneath Los Angeles; one couple, who claims they survived a terrifying abduction; two police helicopter pilots, who find themselves in air combat with a UFO trying to shoot them down; and one man, who endures the unthinkable on a nightly basis.