From the distinct comedic point of view of Denis Leary and Bob Fisher, Sirens follows three of Chicago's best EMTs whose sometimes silly, self-righteous and even self-destructive personalities make them unqualified for sustaining relationships, friendships and most occupations. They are, however, uniquely qualified for saving anyone who winds up in their ambulance. Johnny is a good-looking, sports-loving, Chicago EMT working with his best friend Hank. Brian is a wide-eyed and excitable new EMT who still lives with his parents. Theresa, a smart female cop with the Chicago PD still loves her ex Johnny, but ultimately has to move on when he wouldn't commit.