Wives with Knives features gripping stories of women who fight at close range. Some women endured years of sexual, emotional, and physical abuse before fighting back. Others were motivated by greed and jealousy. Some of the victims died and others lived to testify against their attackers. Through personal accounts from the actual women who committed the crimes, as well as the victims themselves, each episode reveals the traumatic events that led to the pair's disturbing demise.