With first hand accounts and commentary from medical professionals, each half-hour episode sends viewers on an unrestricted journey into an entirely new world of sex. The focus of the show will be bizarre conditions, such as the fictional sex addiction, fetishes and kinky sexual behavior.

An Iraq war veteran who only experiences pain during intercourse and a former Broadway star and sex educator who learned to "think" herself into having an orgasm would be some of the cases featured in the series. Other examples are someone with balloon fetish and a woman who wants orgasm during childbirth.