Threat Matrix is a one-hour drama about a highly specialized, elite task force created to respond to the Threat Matrix report, a document that is presented to the President every morning, identifying the current greatest threats to U.S. security. The team's mission is to keep the country safe from international and domestic threats, using their combined expertise and cutting-edge technology to help them fight the many faces of terror and enemies determined to destroy our way of life. Taking audiences behind the headlines and into the world of homeland security, Threat Matrix dramatizes what we are doing in the world of homeland security, why we are doing it and whether or not it is working.

The leader of this unit is Special Agent John Kilmer. This former FBI agent has White House authorization to call upon the technical skills, firepower and the specialist agents of the FBI, CIA and NSA, among others. Kilmer reports to Colonel Roger Atkins, the operations liaison to the President. Kilmer's ex-wife, Special Agent Frankie Ellroy-Kilmer, is a highly trained interrogation expert and 'profiler' whose skills allow her to crack the most hardened enemies. The rest of Kilmer's team includes Mo, the Egyptian-American former CIA operative; Lia "Lark" Larkin, a former FBI forensics specialist; Tim Serrano, a DEA agent from Miami; and Jelani, an African-American computer genius who intercepts phone, fax and radio signals from around the world and supports the team with the latest NSA technology.