How to Make It in America follows two enterprising Brooklyn twentysomethings as they hustle their way through New York City, determined to achieve the American Dream. Trying to make a name for themselves in New York's competitive fashion scene, Ben Epstein and his friend and business partner Cam Calderon use their street knowledge and connections to bring their ambitions to fruition. With the help of Cam's cousin Rene, who is trying to market his own high-energy drink, and their well-connected friend Domingo, the burgeoning entrepreneurs set out to make it big, encountering obstacles along the way that will require all their ingenuity to overcome.